What is Trump Derangement Syndrome and how does it manifest in social situations?

Trump Derangement Syndrome manifests as an irrational, emotional response when President Trump is mentioned in conversation. As described in the clip, people affected by this condition become completely unreasonable, reacting as if they've been 'shot with a dart in the jugular that contained methamphetamine and rabies.' This syndrome prevents normal conversation, as demonstrated by the speaker's experience at a friend's birthday dinner in LA. When they simply mentioned the President's name, other guests had extreme reactions that made rational discussion impossible. The syndrome transforms otherwise regular social interactions into charged situations where people lose their ability to engage in reasonable dialogue.